Bacoside A

Chemical structure of bacoside A3, a major constituent of bacoside A

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri. Its major constituents include the saponins bacoside A3, bacopaside II, bacopasaponin C, and jujubogenin isomer of bacopasaponin C. The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.

References

  1. ^ Majumdar; et al. (2013). "Bacosides and Neuroprotection". Natural Products: 3639–3660. doi:10.1007/978-3-642-22144-6_157. ISBN 978-3-642-22143-9.
  2. ^ M. Deepak; G. K. Sangli; P. C. Arun; A. Amit (January–February 2005). "Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC". Phytochemical Analysis. 16 (1): 24–29. doi:10.1002/pca.805. PMID 15688952.
  3. ^ "Bacoside A, mixture of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C". Sigma-Aldrich.
  4. ^ Thomas, RB; Joy, S; Ajayan, MS; Paulose, CS (2013). "Neuroprotective Potential of Bacopa monnieri and Bacoside a Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats". Cellular and Molecular Neurobiology. 33 (8): 1065–74. doi:10.1007/s10571-013-9973-0. PMID 23975094. S2CID 9733669.
  5. ^ Russo; Borrelli (2005). "Bacopa monniera, a reputed nootropic plant: an overview". Phytomedicine. 12 (4): 305–317. doi:10.1016/j.phymed.2003.12.008. PMID 15898709.
  6. ^ Aguiar and Borowski, 2013. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Research. http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1431
  7. ^ Bhattacharya, SK; Bhattacharya, A; Kumar, A; Ghosal, S (2000). "Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus". Phytother Res. 14 (3): 174–179. doi:10.1002/(sici)1099-1573(200005)14:3<174::aid-ptr624>3.0.co;2-o. PMID 10815010.
  8. ^ Anbarasi, K; Vani, G; Balakrishna, K; Devi, CS (2006). "Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats". Life Sci. 78 (12): 1378–1384. doi:10.1016/j.lfs.2005.07.030. PMID 16226278.
  9. ^ Anbarasi, K; Sabitha, KE; Devi, CS (2005). "Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A.". Environ Toxicol Pharmacol. 20 (2): 345–350. doi:10.1016/j.etap.2005.03.006. PMID 21783610.
  10. ^ Vohora, D; Pal, SN; Pillai, KK (2000). "Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant". J Ethnopharmacol. 71 (3): 383–390. doi:10.1016/s0378-8741(99)00213-5. PMID 10940574.
  11. ^ Hota, SK; Barhwal, K; Baitharu, I; Prasad, D; Singh, SB; Ilavazhagan, G (2009). "Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment". Neurobiol Dis. 34 (1): 23–39. doi:10.1016/j.nbd.2008.12.006. PMID 19154788. S2CID 207064319.


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