| chemokine (C-C motif) ligand 26 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCL26 | ||||||
| Alt. symbols | SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 | ||||||
| NCBI gene | 10344 | ||||||
| HGNC | 10625 | ||||||
| OMIM | 604697 | ||||||
| PDB | 1G2T | ||||||
| RefSeq | NM_006072 | ||||||
| UniProt | Q9Y258 | ||||||
| Other data | |||||||
| Locus | Chr. 7 q11.2 | ||||||
| |||||||
Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. This gene for chemokine is located on human chromosome 7.
References
- ^ Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
- ^ Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
- ^ Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
- ^ Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.
External links
- CCL26 human gene location in the UCSC Genome Browser.
- CCL26 human gene details in the UCSC Genome Browser.
