Fyn-related kinase

FRK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM: 606573; MGI: 103265; HomoloGene: 48065; GeneCards: FRK; OMA:FRK - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	116,060,891 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	34,487,274 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; buccal mucosa cell; ; palpebral conjunctiva; ; parotid gland; ; sperm; ; corpus epididymis;
	Top expressed in
	seminal vesicula; ; jejunum; ; duodenum; ; renal pelvis; ; conjunctival fornix; ; large intestine; ; colon; ; inner renal medulla; ; left colon; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; signaling receptor binding; ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity;
Cellular component	extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; intracellular anatomical structure; extracellular exosome; extracellular region; nucleus; nucleoplasm; cytoplasm; azurophil granule lumen; specific granule lumen; cytosol;
Biological process	cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of transcription by RNA polymerase II; protein phosphorylation; peptidyl-tyrosine autophosphorylation; innate immune response; negative regulation of cell population proliferation; neutrophil degranulation; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	2444
	14302
	ENSG00000111816
	ENSMUSG00000019779
	P42685
	Q922K9
	NM_002031
	NM_001159544; NM_010237; NM_001358769
	NP_002022
	NP_001153016; NP_034367; NP_001345698
	Wikidata
View/Edit Human	View/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Interactions

FRK has been shown to interact with retinoblastoma protein.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111816 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019779 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
^ ^a ^b "Entrez Gene: FRK fyn-related kinase".
^ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18). UNITED STATES: 3969–72. ISSN 0008-5472. PMID 7664264.

Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. doi:10.3727/096504003108748438. PMID 12725532.
Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18): 3969–72. PMID 7664264.
Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900. S2CID 23352078.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int. J. Cancer. 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567. S2CID 24095233.
Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease". Neurosci. Lett. 360 (1–2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191. S2CID 11972631.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111816 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019779 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7510261-5] Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.

[entrez-6] "Entrez Gene: FRK fyn-related kinase".

[pmid7664264-7] Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18). UNITED STATES: 3969–72. ISSN 0008-5472. PMID 7664264.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading