Protein-coding gene in the species Homo sapiens
Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene .
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
Interactions
IRS4 has been shown to interact with CRK and NISCH .
References
^ a b c GRCh38: Ensembl release 89: ENSG00000133124 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054667 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family" . J Biol Chem . 272 (34): 21403– 7. doi :10.1074/jbc.272.34.21403 PMID 9261155 . ^ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells" . J Biol Chem . 273 (17): 10726– 32. doi :10.1074/jbc.273.17.10726 PMID 9553137 . ^ a b "Entrez Gene: IRS4 insulin receptor substrate 4" .^ Karas M, Koval A P, Zick Y, LeRoith D (May 2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II" . Endocrinology 142 (5). United States: 1835– 40. doi :10.1210/endo.142.5.8135 ISSN 0013-7227 . PMID 11316748 . ^ Koval AP, Karas M, Zick Y, LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction" . J. Biol. Chem . 273 (24). UNITED STATES: 14780– 7. doi :10.1074/jbc.273.24.14780 ISSN 0021-9258 . PMID 9614078 . ^ Sano H, Liu Simon C H, Lane William S, Piletz John E, Lienhard Gustav E (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS" . J. Biol. Chem . 277 (22). United States: 19439– 47. doi :10.1074/jbc.M111838200 ISSN 0021-9258 . PMID 11912194 .
Further reading
White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action". Mol. Cell. Biochem . 182 (1– 2): 3– 11. doi :10.1023/A:1006806722619 . PMID 9609109 . S2CID 32623861 . Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction" . J. Biol. Chem . 273 (24): 14780– 7. doi :10.1074/jbc.273.24.14780 PMID 9614078 . Uchida T, Myers MG, White MF (2000). "IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis" . Mol. Cell. Biol . 20 (1): 126– 38. doi :10.1128/MCB.20.1.126-138.2000 . PMC 85068 PMID 10594015 . Karas M, Koval AP, Zick Y, LeRoith D (2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II" . Endocrinology . 142 (5): 1835– 40. doi :10.1210/en.142.5.1835 PMID 11316748 . Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS" . J. Biol. Chem . 277 (22): 19439– 47. doi :10.1074/jbc.M111838200 PMID 11912194 . Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation" . Mol. Cell. Biol . 22 (13): 4567– 78. doi :10.1128/MCB.22.13.4567-4578.2002 . PMC 133908 PMID 12052866 . Schreyer S, Ledwig D, Rakatzi I, et al. (2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor" . Endocrinology . 144 (4): 1211– 8. doi :10.1210/en.2002-220723 PMID 12639902 . Escribano O, Fernández-Moreno MD, Zueco JA, et al. (2003). "Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver" . Hepatology . 37 (6): 1461– 9. doi :10.1053/jhep.2003.50245 PMID 12774026 . S2CID 20484894 . Yen HW, Jakimiuk AJ, Munir I, Magoffin DA (2005). "Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries" . Mol. Hum. Reprod . 10 (7): 473– 9. doi :10.1093/molehr/gah066 PMID 15155816 . Hinsby AM, Olsen JV, Mann M (2004). "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4" . J. Biol. Chem . 279 (45): 46438– 47. doi :10.1074/jbc.M404537200 PMID 15316024 . Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436– 50. Bibcode :2004CBio...14.1436J . doi :10.1016/j.cub.2004.07.051 PMID 15324660 . S2CID 2371325 . Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation" . J. Biol. Chem . 279 (45): 46588– 94. doi :10.1074/jbc.M408067200 PMID 15331607 . Qiu H, Zappacosta F, Su W, et al. (2005). "Interaction between Brk kinase and insulin receptor substrate-4" . Oncogene . 24 (36): 5656– 64. doi :10.1038/sj.onc.1208721 PMID 15870689 . Cuevas EP, Escribano O, Chiloeches A, et al. (2007). "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation". J. Hepatol . 46 (6): 1089– 98. doi :10.1016/j.jhep.2007.01.031 . PMID 17408801 .
