MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA. It is believed to be involved in skeletal muscle and glucose metabolism. It is upregulated in response to exercise, and is considered an exercise mimetic.
MOTS-c binds to casein kinase 2.
Society and culture
Researchers discovered MOTS-c in 2015.
MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.
References
- ^ Lee, Changhan; Kim, Kyung Hwa; Cohen, Pinchas (1 November 2016). "MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism". Free Radical Biology and Medicine. 100: 182–187. doi:10.1016/j.freeradbiomed.2016.05.015. ISSN 0891-5849. PMC 5116416. PMID 27216708.
- ^ Dieli-Conwright, Christina M.; Sami, Nathalie; Norris, Mary K.; Wan, Junxiang; Kumagai, Hiroshi; Kim, Su-Jeong; Cohen, Pinchas (19 August 2021). "Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors". Scientific Reports. 11 (1): 16916. Bibcode:2021NatSR..1116916D. doi:10.1038/s41598-021-96419-z. ISSN 2045-2322. PMC 8376922. PMID 34413391.
- ^ Kumagai, Hiroshi; Kim, Su-Jeong; Miller, Brendan; Natsume, Toshiharu; Lee, Shin Hyung; Sato, Ayaka; Ramirez, Ricardo; Wan, Junxiang; Mehta, Hemal H; Yen, Kelvin; Cohen, Pinchas (May 2023). "Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein MOTS-c". Physiology. 38 (S1). doi:10.1152/physiol.2023.38.S1.5725846. ISSN 1548-9213. S2CID 258979715.
- ^ Wan, Wei; Zhang, Lieliang; Lin, Yue; Rao, Xiuqing; Wang, Xifeng; Hua, Fuzhou; Ying, Jun (2023). "Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging". Journal of Translational Medicine. 21 (1): 36. doi:10.1186/s12967-023-03885-2. PMC 9854231. PMID 36670507.
- ^ "Explanation of Key Changes on the 2024 WADA Prohibited List". 13 October 2023. Retrieved 6 December 2023.