Santa Anna may refer to:
Places
- Santa Anna, Texas, a town in Coleman County in Central Texas, US
- Santa Anna, Starr County, Texas, US
- Santa Anna Township, DeWitt County, Illinois, one of townships in DeWitt County, Illinois, US
Ships
- Santa Anna (1522 ship), a 16th-century war ship of the Knights Hospitaller
- Santa Anna (1806 ship), a Spanish ship that a British privateer captured in 1806 that became a whaling ship
People
- Antonio López de Santa Anna (1794–1876), Mexican politician and general
- Santa Anna (Comanche) (c. 1800–1849), Native American tribal leader
