Sirius Red

Sirius Red
Names
IUPAC name
Hexasodium (3E)-4-oxo-7-[[(6E)-5-oxo-7-sulfonato-6-[[2-sulfonato-4-[(4-sulfonatophenyl)diazenyl]phenyl]hydrazinylidene]naphthalen-2-yl]carbamoylamino]-3-[[2-sulfonato-4-[(4-sulfonatophenyl)diazenyl]phenyl]hydrazinylidene]naphthalene-2-sulfonate
Other names
Direct Red 80; Picrosirius Red
Identifiers
3D model (JSmol)
ECHA InfoCard 100.018.208
UNII
  • C1=CC(=CC=C1N=NC2=CC(=C(C=C2)N/N=C/3\C(=O)C4=C(C=C3S(=O)(=O)[O-])C=C(C=C4)NC(=O)NC5=CC6=C(C(=O)/C(=N\NC7=C(C=C(C=C7)N=NC8=CC=C(C=C8)S(=O)(=O)[O-])S(=O)(=O)[O-])/C(=C6)S(=O)(=O)[O-])C=C5)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Properties
C45H26N10Na6O21S6
Molar mass 1373.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Sirius Red F 3B (Direct Red 80) is an azo dye primarily used in staining methods for collagen and amyloid. It has the molecular formula C45H26N10Na6O21S6.

In histology, sirius red staining is used in various domains of diagnostic to observe fibrosis levels in a lot of cases of inflammation induced by cancer, vascular or metabolic pathologies.

In bright field microscopy the following can be observed:

  • The nuclei in yellow
  • The cytoplasm in yellow
  • Collagen fibers in red
  • Muscular fibers in yellow
  • Red blood cells in yellow
Sirius red staining in rat liver, where the red color indicates collagen deposition

See also

References

  1. ^ Dapson, Richard W.; Fagan, C.; Kiernan, John A.; Wickersham, T.W. (March 2011). "Certification procedures for sirius red F3B". Biotechnic & Histochemistry. 86 (3): 133–9. doi:10.3109/10520295.2011.570277. PMID 21417582. S2CID 32655644. Retrieved 2015-08-21.
  2. ^ "Sirius red". Histalim. Retrieved 2015-09-22.
  3. ^ Dwivedi, Durgesh Kumar; Jena, G B (November 2018). "Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of Pharmacology. 391 (11): 1257–1274. doi:10.1007/s00210-018-1540-2. PMID 30066023. S2CID 51890984.

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