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| Routes of administration | Oral |
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| Formula | C20H25NS |
| Molar mass | 311.49 g·mol−1 |
Talsupram (Lu 5-005 or Lu 5-003) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed. Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.
See also
References
- ^ Carlsson A, Fuxe K, Hamberger B, Malmfors T (May 1969). "Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro". British Journal of Pharmacology. 36 (1): 18–28. doi:10.1111/j.1476-5381.1969.tb08299.x. OCLC 6895508396. PMC 1703539. PMID 5768100.
- ^ Pawłowski L, Mazela H (June 1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240–246. doi:10.1007/BF00652248. OCLC 5653283278. PMID 3006113. S2CID 1732297.
- ^ McConathy J, Owens MJ, Kilts CD, Malveaux EJ, Camp VM, Votaw JR, et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology. 31 (6): 705–718. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361.
- ^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology. 28 (3): 332–347. doi:10.1016/S0306-4530(02)00026-4. PMID 12573300. S2CID 23452713.
- ^ "The SSRI Issues" (DOC). healyprozac.com. Retrieved January 3, 2024.
