Fludroxycortide

Fludroxycortide
Clinical data
Trade names	Cordran, Haelan
Other names	6α-Fluoro-16α-hydroxyhydrocortisone 16,17-acetonide; 6α-Fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	D07AC07 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Identifiers
	IUPAC name 6-Fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione;
CAS Number	1524-88-5 ;
PubChem CID	15209;
IUPHAR/BPS	7606;
DrugBank	DB00846 ;
ChemSpider	14475 ;
UNII	8EUL29XUQT;
KEGG	D00328 ;
ChEMBL	ChEMBL1201012 ;
CompTox Dashboard (EPA)	DTXSID2047434 ;
ECHA InfoCard	100.014.724
Chemical and physical data
Formula	C24H33FO6
Molar mass	436.520 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1\C=C5/[C@](C)(CC1)[C@@H]2[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F;
	InChI InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 ; Key:POPFMWWJOGLOIF-XWCQMRHXSA-N ;
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Fludroxycortide (INN, BAN, JAN), also known as flurandrenolide (USAN) and flurandrenolone, is a synthetic topical corticosteroid and is used as an anti-inflammatory treatment for use on skin irritations. Trade names include Haelan (Typharm, UK) and Cordran (by Watson Pharmaceuticals, US).

Fludroxycortide is available in ointment, cream and as an impregnated tape (Haelan tape, Cordran tape). Licensed indications in the United Kingdom include recalcitrant dermatoses.

References

^ CID 15209 from PubChem
^ "Fludroxycortide". Drugs.com. Archived from the original on 2019-08-29. Retrieved 2018-01-23.
^ "Fludroxycortide". Patient.info. 30 August 2022.
^ Haelan Tape Summary of Product Characteristics^{[permanent dead link‍]}
^ Nakamura H, Motoyoshi S, Ishii K, Seto Y, Shimizu M (October 1980). "[Anti-inflammatory activity of a topical glucocorticoid, fludroxycortide tape in experimental animals (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 76 (7): 595–607. doi:10.1254/fpj.76.595. PMID 7215997.

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[1] CID 15209 from PubChem

[2] "Fludroxycortide". Drugs.com. Archived from the original on 2019-08-29. Retrieved 2018-01-23.

[3] "Fludroxycortide". Patient.info. 30 August 2022.

[4] Haelan Tape Summary of Product Characteristics^{[permanent dead link‍]}

[5] Nakamura H, Motoyoshi S, Ishii K, Seto Y, Shimizu M (October 1980). "[Anti-inflammatory activity of a topical glucocorticoid, fludroxycortide tape in experimental animals (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 76 (7): 595–607. doi:10.1254/fpj.76.595. PMID 7215997.