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Fluocortin butyl

Fluocortin butyl
Clinical data
Trade namesLenen, Novoderm, Varlane, Vaspit
Other namesFCB; SHK-203; Fluocortin 21-butylate; Fluocortin butylate; Fluocortolone-21-carboxylate 21-butyl; 6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-oic acid butyl ester
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • Butyl 2-[(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.050.476
Chemical and physical data
FormulaC26H35FO5
Molar mass446.559 g·mol−1
3D model (JSmol)
  • CCCCOC(=O)C(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)F)O)C)C
  • InChI=1S/C26H35FO5/c1-5-6-9-32-24(31)23(30)21-14(2)10-17-16-12-19(27)18-11-15(28)7-8-25(18,3)22(16)20(29)13-26(17,21)4/h7-8,11,14,16-17,19-22,29H,5-6,9-10,12-13H2,1-4H3/t14-,16+,17+,19+,20+,21-,22-,25+,26+/m1/s1
  • Key:XWTIDFOGTCVGQB-FHIVUSPVSA-N

Fluocortin butyl (brand names Lenen, Novoderm, Varlane, Vaspit), or fluocortin 21-butylate, is a synthetic glucocorticoid corticosteroid which is marketed in Germany, Belgium, Luxembourg, Spain, and Italy. Chemically, it is the butyl ester derivative of fluocortin.

It was patented in 1971 and approved for medical use in 1977.

References

  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 563–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 457–. ISBN 978-3-88763-075-1.
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495.


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